The Role of Sperm Chromatin Integrity and DNA Damage on Male Infertility
نویسندگان
چکیده
منابع مشابه
The Role of Sperm Chromatin Integrity and DNA Damage on Male Infertility
Infertility affects approximately a quarter of all couples. Of these cases, roughly half are due to male factors. However, more than 50% of the causes of male factor infertility are still obscure. Contemporary Andrology includes a thorough analysis of the sperm looking at the cellular and subcellular imperfections which may have an adverse effect on fertility. Defects in DNA and chromatin struc...
متن کاملAn evidence-based perspective on the role of sperm chromatin integrity and sperm DNA fragmentation testing in male infertility
tau.amegroups.com © Translational Andrology and Urology. All rights reserved. We read with interest the commentary by Dr. Pandiyan and colleagues (1) about the merit of our recently published clinical practice guidelines for sperm DNA fragmentation (SDF) testing based on clinical scenarios (2). We noted that these authors were quite skeptic about the integration of SDF testing into the clinical...
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This study was conducted to determine chromatin integrity and DNA damage by DNA electrophoresis and comet assays of buffalo fresh and frozen semen. Semen samples were collected from four buffalo bulls and evaluated after freezing for semen motility, viability, sperm abnormalities, chromatin integrity and DNA damage. A significant variation was found in semen parameters after thawing. Highly sig...
متن کاملRole of sperm chromatin abnormalities and DNA damage in male infertility.
Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a highly compact and complex structure and is capable of decondensation-features that must be present in order for a spermatozoon to be considered fertile. Any form of sperm chromatin abnormalities or DNA damage may result in male infertility. In support of this conclusion, it was reported that in-vivo...
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Researchers studying the causes of male infertility have recently focused on the role played by reactive oxygen species (ROS)—a highly reactive oxidizing agent belonging to the class of free radicals. ROS are produced by a variety of semen components, and antioxidants in the seminal fluid keep their levels in check. Small amounts of ROS help spermatozoa acquire their necessary fertilizing capab...
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ژورنال
عنوان ژورنال: The Open Reproductive Science Journal
سال: 2011
ISSN: 1874-2556
DOI: 10.2174/1874255601103010065